Brandon dekosky

Brandon DeKosky . CONTRACTING ORGANIZATION: The University of Kansas Center for Research, Inc. REPORT DATE: August 2021 . TYPE OF REPORT: Annual Report . PREPARED FOR: U.S. Army Medical Research and Materiel Command ... E-Mail: [email protected] 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 5f. WORK UNIT NUMBER: 8. PERFORMING ORGANIZATION REPORT

The Antibody Series is a unique event that brings together top minds and researchers in antibody discovery and development field. After two years of success, combining superb presentations ...I want to thank Dr. Brandon DeKosky, Dr. Young Jo Kim, and Dr… I am excited to announce that I have been selected as a 2022 Barry Goldwater Scholar! Liked by Gillian BennettMonoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine, however, the repeated administration of mAbs can be highly immunogenic. Drug immunogenicity manifests in the generation of anti-drug antibodies (ADAs), and some mAbs show immunogenicity in up to 70% of patients. ADAs can alter a drug’s pharmacokinetic and pharmacodynamic properties, reducing drug efficacy ...Brandon DEKOSKY, Assistant Professor | Cited by 3,357 | of University of Kansas, Kansas (KU) | Read 69 publications | Contact Brandon DEKOSKY. Home. University of Kansas. …The Insider Trading Activity of Buhler Brandon B on Markets Insider. Indices Commodities Currencies StocksBrandon DeKosky, a spring 2010 graduate in chemical engineering from Overland Park, recently earned second place in the 2010 American Institute of Chemical Engineers senior design competition. DeKosky was recognized for his design of a manufacturing facility to produce anti-cancer antibodies. He will receive the award in a …Graduate students who participate (left to right): Apollo Stacy, Dr. Greg Clark, Aimee Wessel, Inga Jarmoskaite, Brandon DeKosky, Peter Enyeart, Josh Russell, Marisa Miller, Gabriel Wu, Stephanie Taylor, Damon Polioudakis, Brant Gracia Photo by Marsha Miller

Brandon J. DeKosky - Immune Engineering Lab B cell receptors, T cell receptors, single-cell analysis, infectious diseases, high-throughput screening, infectious diseases, cancer therapeutics. Current Projects: High-throughput antibody screening technologies and computational approaches for rapid drug discovery The current low-throughput ...May 31, 2021 · DeKosky BJ, Lungu OI, Park D, Johnson EL, Charab W, Chrysostomou C, et al.. Large-Scale Sequence and Structural Comparisons of Human Naive and Antigen-Experienced Antibody Repertoires. Proc Natl Acad Sci USA (2016) 113 (19):E2636–45. 10.1073/pnas.1525510113 [PMC free article] [Google Scholar] In this episode of The Chain, Brandon Dekosky, Associate Professor at MIT, speaks with Adrian Bot, Founding Chief Scientific Officer and Executive Vice President of R&D at Capstan Therapeutics, about his experiences in leadership roles, his scientific journey, and how he started work on immunotherapy for cancer.Brandon DeKosky Research Interests biotechnology, vaccines, molecular immunology, single cell analysis, antibodies, t cell receptors, immune biomaterials, protein drug development“AIDS vaccine development has been a decades-long challenge partly because our immune systems have difficulty recognizing all the diverse variants of the rapidly mutating HIV virus, which is the cause of AIDS,” said Brandon DeKosky, assistant professor of pharmaceutical chemistry and chemical & petroleum engineering at the …Chronic traumatic encephalopathy (CTE) is a neurodegenerative syndrome that has been linked to serious psychiatric symptoms, including depression, aggression, and suicidal behavior. This review critically examines the extant research on the behavioral manifestations of CTE and concludes that the paucity of longitudinal prospective studies on CTE, combined with a lack of research-accepted ...The whole content of this chapter was initially published in DeKosky, B.J. et al. High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nat. Biotechnol. 31, 166-169 (2013), and it is reproduced here. B.J.D. and G.G. developed the methodology and designed the experiments.Clinical Data and Demographics. Subjects were identified from a prospective institutional transplant database. Patients were included if they had undergone LT alone between 1/2000-12/2018 and then required re-transplant for CR, which was confirmed on explant pathology.

The following articles are merged in Scholar. Their combined citations are counted only for the first article.Brandon J. DeKosky joined the Department of Chemical Engineering as an assistant professor in a newly introduced joint faculty position between the department and the Ragon Institute of MGH, MIT and Harvard in September 2021. He received his BS in chemical engineering from University of Kansas, and his PhD in chemical engineering from the ...Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine, however, the repeated administration of mAbs can be highly immunogenic. Drug immunogenicity manifests in the generation of anti-drug antibodies (ADAs), and some mAbs show immunogenicity in up to 70% of patients. ADAs can alter a drug’s pharmacokinetic and pharmacodynamic properties, reducing drug efficacy ...Click for more on new School of Pharmacy study in journal PNASKI members Michael Birnbaum, Ömer Yilmaz, Brandon DeKosky and Regina Barzilay, as well as their MIT colleague Seychelle Vos, have been shortlisted by Cancer Research UK and the National Cancer Institute for the Cancer Grand Challenges as part of teams MATCHMAKERS, PROSPECT and KOODAC. If selected, these global, interdisciplinary teams will ...

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Immunoglobulin/T Cell Receptor Capture Strategy for Comprehensive Immunogenetics. James Peter Stewart, Jana Gazdova, Shambhavi Srivastava, Julia Revolta, Louise Harewood, Manisha Maurya, Nikos Darzentas, and David Gonzalez. Published online: May 28, 2022. 1.Brandon DeKosky The Ragon Institute of MGH, MIT, and Harvard: Cambridge, MA, US 2021-09-01 to present | Core Member Employment Show more detail Source : Brandon DeKosky Massachusetts Institute of Technology: Cambridge, MA, US 2021-09-01 to 2023-02-28 | Assistant Professor (Chemical Engineering) Employment Show more detail Source : Brandon DeKoskysaid Brandon DeKosky, assistant professor of pharmaceutical chemistry and chemical & petroleum engineering at the University of Kansas. In the past five years, tremendous progress has been made in ...Brandon J. DeKosky , PhD. Phillip and Susan Ragon Career Development Professor of Chemical Engineering . Associate Professor of Chemical Engineering. Heather J. Kulik, PhD. ... W. A. Tisdale, B. DeKosky. 10.31 Nanoscale Energy Transport Processes. Subject meets with 10.51 Prereq: ...I am a postdoctoral research fellow at Vanderbilt University, and I recently defended my PhD in Microbe-Host Interactions. My research interests focus on investigating antibody-antigen ...Brandon Lucke-Wold, Kay Seidel, Rub Udo, Bennet Omalu, Mark Ornstein, Richard Nolan, Charles L. Rosen, Joel Ross ... M. Ilyas Kamboh, Steven T. DeKosky, Julian E. Bailes. Former Bengal Henry Found ...

"These technologies are providing a new window on human immune protection that we have never been able to see before," said co-lead author Brandon DeKosky, assistant professor of chemical & petroleum engineering and pharmaceutical chemistry at the University of Kansas. "They will dramatically accelerate antibody drug development and may also ...Katie Galloway is the W. M. Keck Career Development Professor in Biomedical Engineering and Chemical Engineering at Massachusetts Institute of Technology (MIT). Her research focuses on elucidating the fundamental principles of integrating synthetic circuitry to drive cellular behaviors. Her lab focuses on developing integrated gene circuits and ...SILVIA OGBEIDE Simona Patange, Ph.D. Chaim Schramm Brandon DeKosky Sevahn… Thank you to our speakers at the 2023 FDA Single Cell Omics Symposium! Liked by Wenming XiaoShort Courses* October 6-8, 2020 *Separate registration is required, see Registration Page for pricing details ImmunogenicitySummit.com | 5 TUESDAY, OCTOBER 6 11:35 AM-1:05 PMDeKosky said key innovations set the stage for this new research, including the development of protein display systems in the 1990s, improvements to antibody discovery beginning in the 2000s and the development of technologies to identify natively paired antibody sequences in the 2010s.Moderator: Brandon DeKosky, PhD, Assistant Professor, The University of Kansas . How to rescue immunogenic lead candidates; Understanding the mechanisms of epitope spreading; Advantageous vs. benign vs. harmful immunogenicity; Optimal monitoring and assay development for immunogenicity analysisBy contrast, previous studies have shown that only about 10 percent of the antibodies generated using techniques that rely on the random pairing of heavy- and light-chain genes are antigen-specific, says Brandon DeKosky, a graduate student in the Georgiou lab who helped to develop the technique. Pros: Very fast.We are delighted to announce that the Board of Directors has selected Dr. Brandon DeKosky as the 2022 James S. Huston Antibody Science Talent Award… Liked by Emily CoatesBrandon Dekosky, University of Kansas Lawrence . 2016 Early Independence Award . National Institute of Dental and Craniofacial Research . National Institute of Allergy and Infectious Diseases . 11:40 AM Frugal Science: Democratize Science, Diagnostics and Disease Surveillance . Manu Prakash, Stanford University . 2015 New Innovator AwardWe developed a new high-throughput approach to enable repertoire-scale functional evaluations of natively paired TCRs. In particular, we leveraged the immortalized nature of physically linked TCRα:β amplicon libraries to analyze binding against multiple recombinant pMHCs on a repertoire scale, and to exemplify the utility of this approach, we ...Cure. These three words embody the spirit of what we represent at the Ragon Institute of Mass General, MIT, and Harvard. We're proud to announce our new logo — and tagline — as part of an institute-wide rebrand ahead of the opening of our new building next year! Our updated visual identity combines elements of unity, collaboration, and ...Assistant Professor Brandon DeKosky received the Miller Award for Research. The full recognition video is available on the School of Engineering's YouTube Channel called Jayhawk Engineering. Congratulations to our award-winning faculty for receiving these distinctive honors. We also send a huge Thank You to them for their dedication to our ...

DeKosky said key innovations set the stage for this new research, including the development of protein display systems in the 1990s, improvements to antibody discovery beginning in the 2000s and the development of technologies to identify natively paired antibody sequences in the 2010s.

New research from the Sprenger and Whitehead groups aims to identify and map common mutations in "Spike" proteins—the proteins that allow the virus to enter and infect cells. This would provide researchers with a roadmap to anticipate and counteract the development of future SARS-CoV-2 strains with effective vaccines and vaccine boosters.Brandon DeKosky of the Department of Chemical Engineering received the Antibody Society's James S. Huston Antibody Science Talent Award on Oct. 20. Lee Gehrke of the Institute for Medical Engineering and Science was named a 2022 National Academy of Inventors Fellow on Dec. 8.Gwo-Yu Chuang 1† Chen-Hsiang Shen 1† Crystal Sao-Fong Cheung 1† Jason Gorman 1† Adrian Creanga 1 M. Gordon Joyce 1 Kwanyee Leung 1 Reda Rawi 1 Lingshu Wang 1 Eun Sung Yang 1 Yongping Yang 1 Baoshan Zhang 1 Yi Zhang 1 Masaru Kanekiyo 1 Tongqing Zhou 1 Brandon J. DeKosky 2 Barney S. Graham 1 John R. Mascola 1 Peter D. Kwong 1*Feb 17, 2022 · We developed a new high-throughput approach to enable repertoire-scale functional evaluations of natively paired TCRs. In particular, we leveraged the immortalized nature of physically linked TCRα:β amplicon libraries to analyze binding against multiple recombinant pMHCs on a repertoire scale, and to exemplify the utility of this approach, we ... The AIRR Community Guide to Quality Control: Chain Pairing Precision and Monitoring of Cross-Sample Contamination. Chung C-Y, Gutiérrez-González M, López Acevedo SN, Fahad AS, DeKosky BJ. Immunogenetics: Methods and Protocols, Methods in Molecular Biology, y, (Springer Nature) ISBN: 9781071621141 , 2022. Antibodies Computational immunology ...Brandon J. DeKosky joined the Department of Chemical Engineering as an assistant professor in a newly introduced joint faculty position between the department and the Ragon Institute of MGH, MIT and Harvard in September 2021. He received his BS in chemical engineering from University of Kansas, and his PhD in chemical engineering from the ...Brandon DeKosky. Nathan Dormer. William Gilbert. Patricia A. Huber. Anisha Patel. Joseph Lomakin. 2009 Annual Meeting. Associated proceedings: 2009 Annual Meeting. Access to contact information is restricted to users who have purchased the conference's Online Proceedings, or received access to the proceedings as part of the conference Registration.

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Proud! Immensely proud. Antibody biologists and engineers and others interested in this topic: just read this conceptual review on a topic we are very… | 22 comments on LinkedInDr. Brandon DeKosky is an assistant professor in the Department of Chemical Engineering at MIT and a core member of the Ragon Institute of Massachusetts General Hospital, Harvard, and MIT. Research efforts at the DeKosky lab have developed a suite of high-throughput single-cell platforms for large-scale analyses of adaptive immunity.Jan 17, 2018 · DeKosky said key innovations set the stage for this new research, including the development of protein display systems in the 1990s, improvements to antibody discovery beginning in the 2000s and ... Jun 1, 2017 · 4.2.1 VH:VL Gene Usage Across B Cell Subsets. We analyzed the peripheral blood antibody repertoire of three human donors using the single B cell VH:VL sequencing technique reported and described in Chapter Four []. Amen Hailmariam, of Lawrence, is a junior at KU studying biochemistry. Hailmariam is a scholar of the IMSD Program, and she is mentored by Brandon DeKosky, assistant professor of pharmaceutical chemistry and chemical engineering. Briana Marsh, of Eureka, Missouri, is a senior at KU studying neuroscience.KU faculty members mentor students around the world.Brandon Dekosky, MIT Ratmir Derda, University of Alberta, Canada Mark Howarth, University of Cambridge, United Kingdom Andreas Pluckthun, University of Zürich, Switzerland Jasna Rakonjac, Massey University, New Zealand Sachdev Sidhu, University of Toronto, Canada Don Siegel, University of Pennsylvania George Smith, University of MissouriBrandon DeKosky, Ph.D., University of Kansas: Molecular analysis of antibody responses associated with COVID-19 respiratory distress; Marta Maria Gaglia, Ph.D., Tufts University: Control of innate immune responses by SARS-CoV-2;Scott Boyd, Stanford University Brandon Dekosky, University of Kansas Ratmir Derda, University of Alberta, Canada Birgit Dreier, University of Zurich, Switzerland Ivo Lorenz, Tri-Institutional Therapeutics Discovery Institute Aimee Payne, University of Pennsylvania Christoph Rader, The Scripps Research Institute Don Siegel, University of Pennsylvania Medical CenterEurope PMC is an archive of life sciences journal literature. https://orcid.org ….

Brandon DeKosky The Ragon Institute of MGH, MIT, and Harvard: Cambridge, MA, US 2021-09-01 to present | Core Member Employment Show more detail Source : Brandon DeKosky Massachusetts Institute of Technology: Cambridge, MA, US 2021-09-01 to 2023-02-28 | Assistant Professor (Chemical Engineering) Employment Show more detail Source : Brandon DeKoskyBrandon DeKosky (center left) and graduate student trainees Rukmini Ladi, Bailey Banach, and Ahmed Fahad (from left).Jun 23, 2022 · Bailey B Banach 1 , Prabhanshu Tripathi 2 , Lais Da Silva Pereira 2 , Jason Gorman 2 , Thuy Duong Nguyen 3 , Marlon Dillon 2 , Ahmed S Fahad 3 , Patience K Kiyuka 2 , Bharat Madan 3 , Jacy R Wolfe 3 , Brian Bonilla 2 , Barbara Flynn 2 , Joseph R Francica 2 , Nicholas K Hurlburt 4 , Neville K Kisalu 2 , Tracy Liu 2 , Li Ou 2 , Reda Rawi 2 , Arne ... Starting Fall 2021, Brandon DeKosky will be joining the MIT Chemical Engineering Department in a newly introduced joint faculty position between the department and the Ragon Institute of MGH, MIT and Harvard, which seeks to address infectious disease by harnessing the human immune system.Brandon Dekosky. Assistant Professor at MIT. See All Speakers. THE ANTIBODY SERIES 2023. The Antibody Series is the annual event bringing together world leading industry and academic experts in the field of antibody discovery and development to discuss and share innovative ideas to advance science.Brandon J. DeKoskyAuthors Info & Affiliations. Science. 4 Sep 2020. Vol 369, Issue 6508. pp. 1167-1168. DOI: 10.1126/science.abe0010 · PREVIOUS ARTICLE. Can ...pCT-VHVL-K1 has been previously reported for Fab yeast surface display expression under a galactose-inducible bidirectional promoter (Wang, DeKosky et al. 2018) (Supplementary Fig. 1).We used pCT-VHVL-K1 as a template for vector construction and performed site-directed mutagenesis to add a stop codon to the VL gene, and to delete the IGHC & leucine zipper regions.Brandon DeKosky. The Ragon Institute of MGH, MIT, and Harvard: Cambridge, MA, US. 2021-09-01 to present | Core Member. Employment. Show more … Brandon dekosky, A new technology can screen orders of magnitude more antibodies than existing methods. Elly Earls finds out why this breakthrough could vastly improve our understanding of how to leverage the immune system to prevent and cure disease Elly Earls Brandon DeKosky Elly Earls Brandon DeKosky Elly Earls Brandon DeKosky Elly Earls Brandon DeKosky …, The new screen works by focusing on two specific regions of the antibody – the VH and the LH [1] — as author Brandon DeKosky explains: “Antibody molecules are encoded by B cells and are assembled from two different genes, called the heavy and light chains. The VH and VL portions – derived from the heavy and light chains, ..., 18.08.2023 г. ... D., University of Wisconsin-Madison, Brandon DeKosky, Ph.D., Massachusetts Institute of Technology, and Eunyong Park, Ph.D., University of ..., 4. Brandon Dekosky, Ph.D - Kansas University • Exploring Personalization of Human Immune Responses with High-Throughput Immune Receptor Data. 5. Live Q/A with all speakers (20min) 50 min intermission, resume at 1:00pm . 1:00pm - 2:50pm . Session 3: Modeling of desired immunogenicity to inform development of vaccines/allergenics 1., In this episode of The Chain, Brandon Dekosky, Associate Professor at MIT, speaks with Adrian Bot, Founding Chief Scientific Officer and Executive Vice President of R&D at Capstan Therapeutics, about his experiences in leadership roles, his scientific journey, and how he started work on immunotherapy for cancer., The University of Kansas is a public institution governed by the Kansas Board of Regents., A primary future direction for paired heavy:light sequencing is to analyze the features of various B cell subsets. The work presented here analyzed the sequence and structural differences between naïve and antigen-experienced B cells [], uncovering a number of unreported features regarding the development and maturation of the human B cell repertoire in healthy adults., MIDD Immunogenicity Workshop June 9th, 2021 - 8:00am - 5:00pm . Opening Remarks (8:00 - 8:30am) Peter Marks, MD, Ph.D. Director Center for Biologics Evaluation and Research, Brandon J DeKosky Present address: Present address: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.,, Mark Liddament posted on LinkedIn, Brandon DeKosky, Ph.D., University of Kansas: Molecular analysis of antibody responses associated with COVID-19 respiratory distress; Marta Maria Gaglia, Ph.D., Tufts University: Control of innate immune responses by SARS-CoV-2;, 5.10.2021 г. ... ... Brandon J. DeKosky ([email protected]). Materials availability. Plasmids for antibody 910-30 generated in this study are available upon request ..., Bio: Dr. Brandon DeKosky is an Associate Professor in the Department of Chemical Engineering at MIT and a Core Member of the Ragon Institute of MGH, …, I want to thank Dr. Brandon DeKosky, Dr. Young Jo Kim, and Dr… I am excited to announce that I have been selected as a 2022 Barry Goldwater Scholar! Liked by Gillian Bennett, I want to thank Dr. Brandon DeKosky, Dr. Young Jo Kim, and Dr… I am excited to announce that I have been selected as a 2022 Barry Goldwater Scholar! I want to thank Dr. Brandon DeKosky, Dr ..., Brandon J. DeKosky , PhD. Phillip and Susan Ragon Career Development Professor of Chemical Engineering . Associate Professor of Chemical Engineering. Heather J. Kulik, PhD. ... W. A. Tisdale, B. DeKosky. 10.31 Nanoscale Energy Transport Processes. Subject meets with 10.51 Prereq: ..., 4.2.1 VH:VL Gene Usage Across B Cell Subsets. We analyzed the peripheral blood antibody repertoire of three human donors using the single B cell VH:VL sequencing technique reported and described in Chapter Four [].Peripheral blood mononuclear cells (PBMC) isolated from three human donors were sorted by FACS to discriminate CD3 − 19 + 20 + 27 − naïve B cell and CD3 − 19 + 20 + 27 ..., Next Generation Vaccine Technologies - Hertz Fellow Brandon DeKosky Works to Prevent HIV. All News. June 2, 2015. Hertz Staff. Livermore, Calif ..., Mark Liddament posted on LinkedIn, Inventors: Scott Hunicke-Smith, Brandon Dekosky, Andy Ellington, George Georgiou HIGH THROUGHPUT SEQUENCING OF MULTIPLE TRANSCRIPTS OF A SINGLE CELL. Publication number: 20150141261 ..., Graduate students who participate (left to right): Apollo Stacy, Dr. Greg Clark, Aimee Wessel, Inga Jarmoskaite, Brandon DeKosky, Peter Enyeart, Josh Russell, Marisa Miller, Gabriel Wu, Stephanie Taylor, Damon Polioudakis, Brant Gracia Photo by Marsha Miller, Anna Vaisman-Mentesh 1 Matias Gutierrez-Gonzalez 2 Brandon J. DeKosky 2,3 Yariv Wine 1* 1 George S. Wise Faculty of Life Sciences, School of Molecular Cell Biology and ... Vaisman-Mentesh A, Gutierrez-Gonzalez M, DeKosky BJ and Wine Y (2020) The Molecular Mechanisms That Underlie the Immune Biology of Anti-drug Antibody Formation Following ..., Congratulations to KI members Michael Birnbaum, Ömer Yilmaz, Brandon DeKosky and Regina Barzilay, along with their MIT colleague Seychelle Vos, on… Liked by Yuyan Cai, Brandon Dekosky. Assistant Professor at MIT. See All Speakers. THE ANTIBODY SERIES 2023. The Antibody Series is the annual event bringing together world leading industry and academic experts in the field of antibody discovery and development to discuss and share innovative ideas to advance science., Biotechnology Vaccines Molecular Immunology Single Cell Analysis Antibodies T Cell Receptors Immune Biomaterials Protein Drug Development, SILVIA OGBEIDE Simona Patange, Ph.D. Chaim Schramm Brandon DeKosky Sevahn… Thank you to our speakers at the 2023 FDA Single Cell Omics Symposium! Liked by Wenming Xiao, The following individual involved in review of your submission has agreed to reveal their identity: Brandon Dekosky (Reviewer #3). The reviewers have discussed the reviews with one another and the Reviewing Editor has drafted this decision to help you prepare a revised submission., Professional football players who wore the No. 27 jersey include Ken Houston, Robert Hubbard and Brandon Jacobs. Houston also wore the No. 29 jersey, while Hubbard donned several other uniform numbers throughout his career, including 36, 40..., Brandon J. DeKosky. I really enjoy the environment for immunology and biotech research here at Ragon, MIT, and Cambridge, there are so many incredibly talented people to …, The cryo-EM structure of 315-19-1D12 Fab in complex with the hemagglutinin (HA) trimer revealed the antibody to recognize the helix A region of the HA stem, at the supersite of vulnerability recognized by group 1-specific and by cross-group-neutralizing antibodies. 315-19-1D12 was derived from HV1-2 and KV2-28 genes and appeared to form a new ..., Our 2022 Huston Award recipient, Prof. Brandon DeKosky, describes his experience in this 2-min video. Filed Under: Antibody engineering, Huston Award Tagged With: antibody engineering, Huston Award. The Huston Antibody Science Talent Award competition is open! August 17, 2022 by Janice Reichert., 19.05.2021 г. ... ... Brandon DeKosky with the 2021 Miller Professional Development Award for Research. The Miller Professional Development Award for Service ..., The whole content of this chapter was initially published in DeKosky, B.J. et al. High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nat. Biotechnol. 31, 166–169 (2013), and it is reproduced here. B.J.D. and G.G. developed the methodology and designed the experiments.