Cyclic progesterone vs continuous

AUB-O occurs in women as a result of absence of cyclic progesterone due to absence of the corpus luteum and the stimulation of the endometrium by unopposed estrogen . For the correct definition of women with AUB-O, excessive bleeding lasting more than 8 days in the last 6 to 12 months should not be due to pregnancy, diagnosed pelvic and ...

Cyclic combined regimens – For women who are perimenopausal or in early postmenopause, we start with continuous administration of 17-beta estradiol (either transdermal or oral, depending upon underlying comorbidities and patient preference) and cyclic administration of oral micronized progesterone (200 mg/day for the first 12 days of each ...This study investigated the impact of chronic exposure to continuous (CoP4) versus cyclic progesterone (CyP4) alone or in combination with 17β-estradiol (E2) on gene expression profiles targeting bioenergetics, metabolism and inflammation in the adult female rat hippocampus.I will be going on cyclical progesterone, supplemented with 2,000mg of inositol daily, two cups of Spearmint tea, and L-theanine. I have opted to try 3 months of progesterone on its own before adding Spironolactone (I have low blood pressure and Spiro can make that worse), but I am considering adding in the topical Spiro to further combat acne.Oct 24, 2020 · JinglingHellsBells · 25/10/2020 15:29. The dose for continuous is 100mgs daily. The dose for cyclical is 20mgs x 12 days per month. This is on the leaflet in the pack of Utrogestan. Cyclic versions are for women who are not post menopause OR for women who choose to remain on a cycle. Continuous or extended cycle vs. cyclic use of combined hormonal contraceptives for contraception. The Cochrane Database of Systematic Reviews 2014, Issue 7. Art. No.: CD004695 . doi: 10.1002/14651858.CD004695.pub3 Article Locations: Article Location Article Location. Curtis KM, Chrisman CE, Mohllajee AP, Peterson HB. ...The included RCT compared LNG‐IUS versus oral continuous or cyclic medroxyprogesterone (MPA) for treating endometrial hyperplasia. After six months of treatment, there was insufficient evidence to determine whether there was a difference in regression rates between the LNG‐IUS group and the MPA group.Object Moved This document may be found hereFemale sex hormones play an important role in fibroid growth. This makes it possible to shrink fibroids with hormone therapy. The hormones can be used to relieve symptoms or to help prepare for surgery. Some hormone therapies can be used to temporarily relieve heavy menstrual bleeding and period pain. These treatments can also …

Impact of Continuous Versus Discontinuous Progesterone on Estradiol Regulation of Neuron Viability and Sprouting After Entorhinal Cortex Lesion in Female Rats. Endocrinology, Mar 2015 Barron, Anna M., Brown, Meghan A., Morgan, Todd E., …Recurring themes or trends attach themselves to different cycles in the stock market. Stock prices trend lower in some cycles and higher in others. Market cycles can linger for years or be condensed into a number of months; they can even be...require concomitant progestin use. Consensus-based recommendation Recommendation 20 Grade Review use of MHT after 6 months, with regular subsequent reviews to reassess the balance of risks and benefits for the individual. Consensus-based recommendation Recommendation 21 Grade Tibolone should only be used in women >12 months since …It is used in either cyclic or continuous fashion. The most commonly used cyclic regimen consists of conjugated estrogens (Premarin 0.625 mg) to which MPA (Provera) 2.5 or 5 mg is added for the ...received progestogen compared with placebo. Micronized progesterone and MPA were equivalent in providing en-dometrial protection.11 Progestogen intake is recommended with HRT in non-hysterectomized women in a sequential regimen in peri-menopausal women and continuous combined regimen regimens in postmenopausal women. Clinical …Continuous HRT: $ 15.93 (6.60 to 8.95) ... effects of cyclic administration of progesterone from the sustained-release vaginal gel Crinone (4% and 8%) on endometrial morphologic features and ...Cyclic combined regimens – For women who are perimenopausal or in early postmenopause, we start with continuous administration of 17-beta estradiol (either transdermal or oral, depending upon underlying comorbidities and patient preference) and cyclic administration of oral micronized progesterone (200 mg/day for the first 12 days of each ...

Monthly cyclical regimen — oestrogen is taken daily and progestogen is given at the end of the cycle for 10–14 days, depending on the type of progestogen. The suggested dose of progestogen given in a continuous combined HRT regimen is a minimum of 0.5 mg/day of norethisterone or 2.5 mg/day of medroxyprogesterone acetate. ... cyclic progestin, usually medroxyprogesterone (Provera) because of its low cost. If PMS-like side effects are unacceptable, consider micronized progesterone ...Upon receiving the medicine at first, you will likely not know where you are in your cycle so you start the medicine immediately. Within 1-3 days of finishing your 10 day course, you should have a menstrual cycle. This cycle can be significantly heavier than your usual cycle. The day you start bleeding after the medicine, is CYCLE DAY #1. Of 780 studies that were screened by title and abstract, 8 were included in the final analysis; 6 evaluated cyclic vs. continuous CHC, and 2 evaluated cyclic vs. extended/flexible CHC use. Quality of evidence was low for all outcome measures. Overall, compared to cyclic use, flexible/extended CHC resulted in 4 fewer days of dysmenorrhea.Progesterone 14 days per month or Mirena Coil Post Menopause, LMP>1yr ago Combined Continuous HRT = Oestrogen & Progesterone daily OR Oestrogen daily & Mirena Coil Resources Easy HRT Prescribing Guide Top 10 Tips for HRT Prescribing BMS Menopause Videos BMS HRT Risk Chart Assessment: Symptoms Main symptom of concern Impact …

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Dec 4, 2007 · Context: Continuous oral contraception may better suppress the ovary and endometrium, lending itself to the treatment of other medical conditions. Objective: Our objective was to determine the effects of continuous vs. cyclical oral contraception. Design: This was a randomized double-blind trial. Setting: This trial was performed at an academic ... Female sex hormones play an important role in fibroid growth. This makes it possible to shrink fibroids with hormone therapy. The hormones can be used to relieve symptoms or to help prepare for surgery. Some hormone therapies can be used to temporarily relieve heavy menstrual bleeding and period pain. These treatments can also …should be advised to change to continuous progestogen intake using the LNG-IUS or a continuous ... The efficacy of intrauterine versus oral progestin for the ...CEE, 0.625 mg daily, with MPA, 5 or 10 mg, on days 1 through 10 of each month. Withdrawal bleeding occurs monthly after day 10 of progestin and can continue for years. Cyclical HRT is available in a combination pill (Premphase) in which progesterone is present only in the pills for days 12 through 28.Objective To assess the efficacy, safety and acceptability of cyclic medroxyprogesterone acetate (MPA) compared to continuous MPA for treatment of endometrial hyperplasia (EH) without atypia. Materials and methods A prospective observational study conducted on premenopausal women with EH without atypia (n = …

1 Eyl 2023 ... Dosing · Adults—200 milligrams (mg) per day, taken as a single dose at bedtime, for 12 continuous days per 28-day menstrual cycle. · Children—Use ...Key Points. Question Is the risk for venous thromboembolism (VTE) higher with use of extended cyclic and continuous combined oral contraceptives (COCs) (84/7 or 365/0 days cycles) than traditional cyclic COC use (21/7 days cycle), while holding the progestogen type constant (levonorgestrel)?. Findings This cohort study of 733007 in the US …The first large, direct comparison of a continuous OCP (levonorgestrel [LNG] 90 micrograms/ethinyl estradiol 20 micrograms) with a cyclic OCP (LNG 100 micrograms/ethinyl estradiol 20 micrograms) was a randomized, open-label trial in which 323 healthy women were randomized to continuous LNG 90 micrograms/ethinyl estradiol 20 micrograms and 318 ... Nov 15, 2021 · Progesterone is a reproductive hormone, released by your body during its menstrual cycle. As you enter perimenopause, your periods will become more sporadic and less frequent. As a result, your body will slow down and then eventually cease its production of natural progesterone. This reduced level of progesterone is what triggers many of your ... When mammographic breast density was evaluated in the PEPI trial, women randomized to CEE alone, CEE/cyclic MPA, CEE/continuous MPA, or CEE/cyclic P4 had 0.9%, 4.6%, 4.4%, and 3.1% increases in breast density, respectively, compared with placebo (−0.4%; p < 0.001 for combined progestogen group vs. placebo, with no difference among …Cyclic HRT: 14.40: 100 mg once daily: Continuous HRT: 18.90: 400 mg daily in the evening for 10 sequential days: Secondary amenorrhea: 24.00: Crinone: Vaginal gel, prefilled applicators...Continuous cycle pills contain more pills per pack, which means that they can, depending on how they're used: Shorten your monthly periods. Lower the frequency …The administration of 200 mg/day progesterone over 12 days of a menstrual cycle or a daily administration of 100 mg combined with an estrogen are a safe and well-tolerated option to treat menopausal symptoms, with a better benefit risk profile compared to synthetic gestagens. Key words: hormone therapy, progesterone, menopause, menopausal symptomsThis systematic review aims to evaluate the benefits of oral continuous combined hormonal contraceptives (CHCs) in managing dysmenorrhea by comparing …It sounds like the difference for you with 100mg/day vs. 200mg/cyclically sound rather significant. on the other hand, any potential difference in your estrogen production with cyclic or continuous is subtle and also speculation. So I don't see the concerns as of equal value. On a personal note, the 200mg/cyclic progesterone made me quite ... Sep 26, 2021 · This pilot study's purpose was to document 6-month experience changes in a woman with PCOS taking cyclic progesterone therapy because she was intolerant of combined hormonal contraceptive therapy, the current PCOS standard of care. A 31-year-old normal-weight woman with PCOS had heavy flow, irregular cycles, and was combined hormonal ...

17 Eki 2019 ... ... continuous mucus. ... Since this patient could not identify the time of ovulation (due to excessive mucus), she was treated with “cyclic ...

Nervous about getting an IUD inserted? We've got you covered. An intrauterine device (IUD) is a tiny, T-shaped piece of plastic that’s inserted into your uterus to prevent pregnancy. Hormonal IUDs release a small amount of the hormone proge...Estradiol (E2) is the main factor to induce proliferation of the endometrial glands (only represented here), stroma and vessels. Progesterone (P) antagonize the proliferative effect of E2. Hyperplasia results from the constant stimulation of the endometrial glands by E2 in the absence of P or in condition of excess of E2.Hormonal medications (estrogen and progestin methods) for the specific purpose of menstrual suppression should not be initiated before the onset of menarche. ... Jensen JT, Grimes DA. Continuous or extended cycle vs. cyclic use of combined hormonal contraceptives for contraception. The Cochrane Database of Systematic Reviews 2014, …Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles.Cyclic progesterone vs continuous Continuous and Cyclic Progesterone Differentially Interact with ... WebContinuous-combined regimen inhibits the sloughing ...In contrast, cyclic injections of estrogen and progesterone produce high levels of hormone shortly after each injection, which then stabilize in the physiological range and then …Europe PMC is an archive of life sciences journal literature. https://orcid.org20 Nis 2023 ... Menopausal hormone therapy can be given in two ways: cyclical or continuous. ... Micronised progesterone capsules are a natural, body-identical ...

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Moreover, using low-dose estrogen and minimal progesterone in a cyclic manner was reported to effectively produce luteinizing hormone surge [54], to lower the rate of withdrawal bleeding, and to ...Continuous combined HRT is available in the form of a daily tablet or a patch. Th e gel and spray only provide estrogen so if either of these are chosen, a daily separate progestin is n eeded. An example of a continuous combined regimen using micronized progesterone would be Ut rogestan 100mg daily at bedtime along with separate estrogen. In perimenopause, cyclic progesterone may also (especially if ibuprofen is also taken) help decrease heavy flow. Cyclic progesterone also helps with the sleep and premenstrual symptoms in perimenopause. Early menopause (before age 40) can be treated with estradiol and cyclic or daily progesterone. This treatment is continued until a woman ... The study had 2 arms: The estrogen-plus-progestin study of women with a uterus The estrogen-alone study of women without a uterus Women with a uterus were given progestin in combination with estrogen, which is known to prevent endometrial cancer.Overview. " Cyclic Progesterone " means treatment with the natural progesterone hormone ( oral micronized progesterone, Prometrium® or compounded in oil) in a way that mimics the normal pattern (14 days in the last half of the menstrual cycle) and amount (300 mg at bedtime) in the menstrual cycle. That definition may suggest this therapy would ... Objective To assess the efficacy, safety and acceptability of cyclic medroxyprogesterone acetate (MPA) compared to continuous MPA for treatment of endometrial hyperplasia (EH) without atypia. Materials and methods A prospective observational study conducted on premenopausal women with EH without atypia (n = …For cyclic OCPs, with typical use, as contrasted to perfect use, the pregnancy rate is 8% vs 0.3% per year, respectively, showing that missed pills or other reasons for imperfect use cause ...Upon receiving the medicine at first, you will likely not know where you are in your cycle so you start the medicine immediately. Within 1-3 days of finishing your 10 day course, you should have a menstrual cycle. This cycle can be significantly heavier than your usual cycle. The day you start bleeding after the medicine, is CYCLE DAY #1. Continuous combined HRT is available in the form of a daily tablet or a patch. Th e gel and spray only provide estrogen so if either of these are chosen, a daily separate progestin is n eeded. An example of a continuous combined regimen using micronized progesterone would be Ut rogestan 100mg daily at bedtime along with separate estrogen. Continuous cycle pills contain more pills per pack, which means that they can, depending on how they're used: Shorten your monthly periods. Lower the frequency …Although progesterone is commonly used for oligo-amenorrhea assessment (the so called “progestin challenge” test) or for treatment , available published data suggest that cyclic progesterone therapy may be beneficial in PCOS. Two PCOS short-cycle (7 and 10 day) progesterone studies documented decreased serum LH and T levels [19,20].Continuous-combined regimen inhibits the sloughing of mammary epithelium that occurs after progesterone withdrawal in a cyclic regimen. More importantly, the progestins used (medroxyprogesterone acetate and 19-Nortestosterone-derivatives) are endowed with some non-progesterone-like effects, which can potentiate the proliferative action of ... ….

It wasn't too bad on 100mg/day but at 200mg/day I could barely function after a few days taking it cyclically. (To be clear: the usual continuous dose is 100mg/day and the usual cyclic dose is 200mg/day). That said, lots of women, particularly in peri, like the effect of progesterone and it doesn't make them depressed. This study investigated the impact of chronic exposure to continuous (CoP4) versus cyclic progesterone (CyP4) alone or in combination with 17β-estradiol (E2) on gene expression profiles targeting ...Progesterone is a natural hormone and is different from synthetic PROGESTINS, which are commonly prescribed in birth control pills, hormonal IUDs or in ...Progesterone is one of two important hormones for women (estrogen is the one we usually hear about). Menstrual cycle hormone levels can be disturbed, even during regular cycles. The most common disturbance is of ovulation causing progesterone levels to become too low or absent. Your doctor may prescribe progesterone to control heavy …Oct 22, 2021 · Abstract. Uterine adenomyosis is a commonly encountered estrogen-dependent disease in reproductive-age women, causing heavy menstrual bleeding, intense pelvic pain, and infertility. Although adenomyosis was previously considered a disease of multiparous women, it is becoming increasingly evident that it also affects younger nulliparous women ... Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association; Alzheimer’s & Dementia: Translational Research & Clinical InterventionsThis study investigated the impact of chronic exposure to continuous (CoP4) versus cyclic progesterone (CyP4) alone or in combination with 17β-estradiol (E2) on gene expression profiles targeting bioenergetics, metabolism and inflammation in the adult female rat hippocampus. High-throughput qRT-PCR analyses revealed that ovarian …This study investigated the impact of chronic exposure to continuous (CoP4) versus cyclic progesterone (CyP4) alone or in combination with 17β-estradiol (E2) on gene expression profiles targeting bioenergetics, metabolism and inflammation in the adult female rat hippocampus. High-throughput qRT-PCR …Use continuous oestrogen and cyclic progestogen combinations at peri-menopause or if less than 12 months amenorrhoea LOW DOSE ... gel, with micronised progesterone capsules. 1 pump (0.75mg oestradiol) daily, and 2 capsules (200mg) micronised progesterone orally for 12 days out of a 28-day cycle MEDIUM DOSE Cyclic progesterone vs continuous, The treatment period was at least 24 months. The study showed an effective reduction of the risk of recurrence in the two groups taking OCs (p = 0.012 for cyclic use and p = 0.006 for continuous use) but without a difference between the rate in the cyclic and continuous users. The number of recurrences in the three groups was 20/69, 11/75 and 6/73., Moreover, using low-dose estrogen and minimal progesterone in a cyclic manner was reported to effectively produce luteinizing hormone surge [54], to lower the rate of withdrawal bleeding, and to ..., Instructions for menopausal Oral Progesterone treatment are similar to those for pre- and perimenopausal women Cyclic Progesterone Therapy except that the 300-mg dose is taken every day . Take a compounded oral micronized progesterone , rather than Prometrium ® if you are allergic to peanuts because it is dissolved in peanut oil., Continuous versus Cyclic Progesterone Exposure Differentially Regulates Hippocampal Gene Expression and Functional Profiles Liqin Zhao, Todd E. Morgan, Zisu …, Aug 20, 2023 · There are three categories of extended-cycle birth control pills. 91-Day: These continuous birth control pills include the pill brands Seasonale, Quasense, Seasonique, and LoSeasonique. Each pack contains 84 active/hormone pills, which equals 12 weeks of continuous birth control. The pack also has seven inactive pills. , Show simple item record. Continuous versus Cyclic Progesterone Exposure Differentially Regulates Hippocampal Gene Expression and Functional Profiles, It comes as tablets or patches. There are 2 types: monthly HRT if you're having regular periods - you take oestrogen every day, and take progestogen alongside it for the last 10 to 14 days of your menstrual cycle every month. 3-monthly HRT if you're having irregular periods - you take oestrogen every day, and take progestogen alongside it ..., I will be going on cyclical progesterone, supplemented with 2,000mg of inositol daily, two cups of Spearmint tea, and L-theanine. I have opted to try 3 months of progesterone on its own before adding Spironolactone (I have low blood pressure and Spiro can make that worse), but I am considering adding in the topical Spiro to further combat acne., Hi all, I am a 43 year old woman on HRT for Premature Ovarian Insufficiency (POI, formerly POF). I have done copious amounts of research and the take away is the that cyclic micronized oral progesterone (MOP) with a transdermal (TD) estradiol patch is the most effective strategy for preserving bone mineral density (TD or vaginal progesterone …, What are menopause and perimenopause? What is hormone therapy? What are the different types of hormone therapy? How does hormone therapy work? How often is hormone therapy taken? How should I decide whether to take hormone therapy? What are the benefits of hormone therapy? How does hormone therapy affect my risk of cancer? , Modern hormone replacement therapy (HRT) regimens contain oestrogen and progestogen, given either in a cyclical or continuous combined manner. Most endometrial biopsies from women on sequential HRT show weak secretory features. Approximately 15% show proliferative activity, although this figure may be less if more than nine days of …, This study investigated the impact of chronic exposure to continuous (CoP4) versus cyclic progesterone (CyP4) alone or in combination with 17β-estradiol (E2) on …, Cyclic natural (micronized) progesterone 200 mg/day for 21 days a month may be used, particularly if pregnancy is possible; however, it may cause drowsiness and does not decrease blood loss as much as a progestin. If patients using noncontraceptive cyclic progestins or progesterone wish to prevent pregnancy, contraception should be used ..., Continuous HRT: $ 15.93 (6.60 to 8.95) 5 or 10 mg daily for 12 days per month starting on day 1 or day 16: Cyclic HRT: 9.48 (2.64 to 5.40) 5 or 10 mg daily for 5 …, One such parameter is continuous vs. cyclic delivery of the progestogen component of HT. Recent experimental evidence suggests that continuous progesterone can attenuate neural actions of estradiol (E(2)). ... In the present study, we compared the effects of continuous and cyclic progesterone treatment in the presence and absence of E(2) in ..., Interestingly, I came across an animal study comparing cyclic versus continuous progesterone administration that linked cyclic administration to better neuropathological outcomes, but the study says more research is needed (I’m not a scientist , btw, so take my interpretation with a grain of salt). Study published by the Endocrine Society , Download scientific diagram | Continuous but not cyclic progesterone attenuates E 2 's beneficial effect on working memory. A, SAB in the Y-maze significantly differed across treatment groups of 6 ..., With continuous combined hormone replacement therapy, up to 40 percent of women have irregular bleeding in the first four to six months of therapy. 19 Bleeding is more common when hormone therapy ... , continuous progestogen provides better long-term protection than cyclical; DVT/PE: 2-3 background risk, which is 1.7 per 1,000 women aged over 50; greatest risk in 1st 12 months, this risk is not present with non-oral (patch, gel or spray) overall venous thromboembolism (VTE) risk increases about two-fold in women who take oral oestrogens ..., Dec 5, 2020 · 1.1. HMB: The Most Common Complaint. A number of theories have been proposed to explain fibroid-related HMB. These include an increase in uterine surface area, endometrial ulceration or an enlarged vascular network on the surface of a submucosal fibroid, greater vascular flow into the myometrium, changes in contractility of the inner junctional zone, and congestion of the endometrium and ... , Updated Date: December 5, 2018. Progesterone is one of two important hormones for women (estrogen is the one we usually hear about). Menstrual cycle hormone levels …, Extended or continuous cycle combined oral contraceptive pills are a packaging of combined oral contraceptive pills (COCPs) that reduce or eliminate the withdrawal bleeding that would occur once every 28 days in traditionally packaged COCPs. It works by reducing the frequency of the pill-free or placebo days. Extended cycle use of COCPs may also be …, Progestin : เป็น ... Grimes DA, Schulz KF. Skin patch and vaginal ring versus combined oral contraceptives for contraception. Cochrane Database Systematic Review 2003; : CD003552. ... Soltes B, et al. Occurrence of menses or pregnancy after cessation of a continuous oral contraceptive. Fertil Steril 2008; 89:1059. Cunningham …, Dec 15, 1997 · Objectives: To compare continuous and cyclical transdermal estrogen replacement therapy (ERT) with or without an oral progestogen regarding climacteric symptoms, body weight and bleeding pattern. Methods: A total of 2459 postmenopausal women were treated for three cycles of 28 days in an open, randomized, parallel group multicenter study. , The critical importance of ovarian sex steroid hormones (estrogens and progesterone) in promotion and maintenance of the growth of breast cancers was suggested more than 100 years ago when George Beatson demonstrated that bilateral oophorectomy resulted in the remission of breast cancer in a premenopausal woman …, There are three categories of extended-cycle birth control pills. 91-Day: These continuous birth control pills include the pill brands Seasonale, Quasense, Seasonique, and LoSeasonique. Each pack contains 84 active/hormone pills, which equals 12 weeks of continuous birth control. The pack also has seven inactive pills., Progesterone for prevention of bone loss in adolescent, pre- and perimenopause. Oral micronized progesterone (progesterone) that is identical to ovarian luteal-phase P4 production is now available for cyclic therapy Citation 39. However, progesterone therapy only became available in France in the 1980s Citation 39 and North America in the mid ..., Progesterone talks back to the hypothalamic and pituitary (brain) hormones that control the ovary, and stops them from stimulating the ovary to make too much testosterone. Taking progesterone for two weeks every month (called cyclic progesterone) may help the brain to develop the normal cyclic rhythm that is missing in …, Extended Use Instructions. Take 84 hormonal pills in a row, one each day. (These are the hormonal pills in 4 monthly packs.) Users of 28-pill packs do not take the nonhormonal pills. After 84 hormonal pills, wait 7 days and start the next pack of pills on the 8th day., Apr 21, 2010 · The effects of continuous vs. cyclic P4 on development of AD have not been assessed in either clinical or experimental models. In this study, we compared the effects of cyclic vs. continuous P4 in the presence and absence of an E 2, on indices of pathology in the 3×Tg-AD triple transgenic mouse model of AD. , Progesterone is a reproductive hormone, released by your body during its menstrual cycle. As you enter perimenopause, your periods will become more sporadic and less frequent. As a result, your body will slow down and then eventually cease its production of natural progesterone. This reduced level of progesterone is what triggers many of your ..., The effects of continuous vs. cyclic P4 on development of AD have not been assessed in either clinical or experimental models. In this study, we compared the effects of cyclic vs. continuous P4 in the presence and absence of an E 2, on indices of pathology in the 3×Tg-AD triple transgenic mouse model of AD., 20 Nis 2023 ... Menopausal hormone therapy can be given in two ways: cyclical or continuous. ... Micronised progesterone capsules are a natural, body-identical ...